Download winnonlin r software4/9/2023 ![]() ![]() The flavonoid is predominantly excreted via non-renal routes (fe values of 0.16-3.46 %), and undergoes rapid and extensive phase II metabolism. S-liquiritigenin showed a short half-life (0.25-0.54 h), while a better estimation of half-life (26-77 h) and other pharmacokinetic parameters was observed using urinary data. ![]() Serum concentrations were quantified but rapidly fell to undetectable levels. Concentrations in serum and urine were characterized via stereospecific reversed-phase, isocratic HPLC method with UV detection. Liquiritigenin was intravenously (20 mg/kg) and orally (50 mg/kg) administered to male Sprague-Dawley rats (n = 4 per route of administration). In this study, we characterize, for the first time, the stereoselective pharmacokinetics of liquiritigenin. ![]() The nature of its biological fate with respect to the individual enantiomers has not been examined. Liquiritigenin is a chiral flavonoid present in licorice and other medicinal plants. ![]()
0 Comments
Leave a Reply.AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |